Gene and Protein Virtual Lab

The principle: the availability of amino acids influences gene expression

The local availability of amino acids (AA) may be a limiting factor in protein biosynthesis.

The relative abundance of some amino acids can be considered a regulatory factor of protein translation and it can be said that the AA availability can influence gene expression in addition to other mechanisms such as the epigenetic control.

When a protein is enriched in some AA, their availability will control the production of that protein.

The availability of AA can be influenced by many local and general events; for example, any metabolic process consuming AA as intermediate metabolites, starvation or the modulation of AA transporters mediating their entry into the cell.